副研究员
细菌DNA磷硫酰修饰是邓子新院士开拓的我国原创科学研究领域。修饰具有位点专一,立体手性纯度高等特点。实验室长期从事修饰的生理意义、生化及结构机理研究,为核酸修饰药物的开发和制造提供可行性新方案。
1. 天然产物合成机器的冷冻电镜结构解析;
2. 重要代谢合成途径复杂机器的结构和机理研究。
1. DNA硫修饰酶学机制和抗氧化生理意义探究;
2. 天然重要药物合成机器的冷冻电镜单颗粒技术结构解析和生化机理研究。
硫修饰DNA,常用于寡核苷酸药物。寡核苷酸药物的硫修饰是高丰度修饰。细菌生理DNA硫修饰是低丰度事件。细菌硫修饰如何利用低丰度的硫修饰,实现相应的生理功能,相关原理的阐明,可能为反义核酸药物设计提供新的线索。
细菌DNA磷硫酰修饰是邓子新院士开拓的我国原创科学研究领域。修饰具有位点专一,立体手性纯度高等特点。实验室长期从事修饰的生理意义、生化及结构机理研究,为核酸修饰药物的开发和制造提供可行性新方案。
1. 天然产物合成机器的冷冻电镜结构解析;
2. 重要代谢合成途径复杂机器的结构和机理研究。
1. DNA硫修饰酶学机制和抗氧化生理意义探究;
2. 天然重要药物合成机器的冷冻电镜单颗粒技术结构解析和生化机理研究。
硫修饰DNA,常用于寡核苷酸药物。寡核苷酸药物的硫修饰是高丰度修饰。细菌生理DNA硫修饰是低丰度事件。细菌硫修饰如何利用低丰度的硫修饰,实现相应的生理功能,相关原理的阐明,可能为反义核酸药物设计提供新的线索。
Wang J, Wang X, Li X, Kong L, Du Z, Li D, Gou L, Wu H, Cao W, Wang X, Lin S, Shi T, Deng Z, Wang Z, Liang J*. C-N bond formation by a polyketide synthase. Nature Communications. 2023 Mar 10;14(1):1319. Co-corresponding author
Wang J, Li D, Chen L, Cao W, Kong L, Zhang W, Croll T, Deng Z, Liang J*, Wang Z. Catalytic trajectory of a dimeric nonribosomal peptide synthetase subunit with an inserted epimerase domain. Nature Communications. 2022 Feb 1;13(1):592. Co-corresponding author
Wang J#, Liang J#, Chen L, Zhang W, Kong L, Peng C, Su C, Tang Y, Deng X*, and Wang Z*. Structural basis for the biosynthesis of Lovastatin. Nature Communications. 2021 Feb 8;12(1):867. Co-first Author
Pu T, Liang J#, Mei Z, Yang Y, Wang J, Zhang W, Liang W, Zhou X, Deng Z, Wang Z. Phosphorothioated DNA is shielded from oxidative damage. Applied and Environmental Microbiology. 2019 Apr 4;85(8):e00104-19. Selected as Spotlight. Co-first author
Wu H, Liang J#, Wang J, Liang W, Gou L, Wu Q, Zhou X, Bruce IJ, Deng Z, Wang Z. Cezomycin Is Activated by CalC to Its Ester Form for Further Biosynthesis Steps in the Production of Calcimycin in Streptomyces chartreusis NRRL 3882. Applied and Environmental Microbiology. 2018 May 31;84(12). e00586-18. Co-first author
Wu H, Liang J#, Gou L, Wu Q, Liang W, Zhou X, Bruce IJ, Deng Z, Wang Z. Recycling of Overactivated Acyls by a Type II Thioesterase during Calcimycin Biosynthesis in Streptomyces chartreusis NRRL 3882. Applied and Environmental Microbiology. 2018 May 31;84(12). e00587-18. Co-first author
Dai D, Du A, Xiong K, Pu T, Zhou X, Deng Z, Liang J*, He X*, Wang Z*. DNA Phosphorothioate Modification Plays a Role in Peroxides Resistance in Streptomyces lividans. Frontiers in Microbiology. 2016 Aug 31; 7:1380. Co-corresponding author
Xie X, Liang J#, Pu T, Xu F, Yao F, Yang Y, Zhao Y, You D, Zhou X, Deng Z, Wang Z. Phosphorothioate DNA as an antioxidant in bacteria. Nucleic Acids Research. 2012 Oct; 40(18):9115-24. Co-first author